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In these types of individuals, even typical therapeutic doses of Darvocet-N (propoxyphene napsylate and acetaminophen) may perhaps minimize respiratory drive to the point of apnea. In these sufferers option non-opioid analgesics must be considered, and opioids needs to be utilized only beneath thorough health care supervision at the lowest successful dose.

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Soon after oral administration of propoxyphene in clients with cirrhosis, plasma concentrations of propoxyphene had been noticeably larger and norpropoxyphene concentrations had been much lower than in control patients.

The respiratory depressant effects of narcotics as well as their capacity to elevate cerebrospinal fluid pressure might be markedly exaggerated while in the existence of head personal injury, other intracranial lesions or maybe a pre-present increase in intracranial tension.

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